foxo4 dri senolytic 2023 2024 Molecular modelling of the FOXO4-TP53 interaction to design peptides for the elimination of senescent cancer cells ES2 rapidly destroys TP53-FOXO4 foci

ES2 rapidly destroys TP53 FOXO4 foci leading to TP53 mediated Download Scientific Diagram Cellular Senescence in Health, Disease, and Lens Aging The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4 DRI Nature Communications FOXO4 DRI regulates endothelial cell senescence via the P53 signaling pathway PMC FOXO4 DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53 serine 15 phosphorylation Communications Biology

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